レチノイン酸ヒドロキシピナコロン/ HPR/ 893412-73-2

商品名	ヒドロキシピナコロンレチノエート/ HPR
CAS番号	893412-73-2
分子式	C26H38O3
分子量	398.586
分子構造
品質基準	99％アップの粉末形態。液体形態10％アップ
外観	黄色からオレンジ色の結晶性粉末

Hydroxypinacolone Retinoate (Hydroxy pinacone retinoic acid/ HPR) is a retinol derivative, which can directly bind with cellular retinoic acid receptors (RARs), and has the function of regulating the metabolism of the epidermis and stratum corneum. However, retinoic acid ester (HPR) can be converted into retinoic acid (retinoic acid) in a single step of hydrolysis, which has a faster effect. In addition, the stimulation of retinoic acid ester (HPR) is much smaller than that of retinol or retinol ester, and its stability is also very high.

  The big promise of HPR is that it's similarly active as retinoic acid (no conversion needed, remember) but without the irritation. According to the manufacturer's tests, 24 hours of an occlusive

patch with 0.5% HPR resulted in significantly lower irritation than 0.5% retinol. Also, there was a "dramatic reduction of lines and wrinkles" after applying 0.2% HPR around the eyes twice a day for 14 days.

  One of the significant advantages hydroxypinacolone retinoate has over retinol and other vitamin A derivatives used in active ingredient cosmeceuticals today is that it does not require a conversion to retinoic acid. Once applied to the skin it can bind directly to the receptors allowing a cascade of events to take place which produce the antiaging effects, reduction in pigmentation marks and blemishes, improving the appearance of fine lines and wrinkles, reducing sebum production, minimising pores and improving skin texture. Furthermore, increased hydration and an improvement in the glow of the skin can also be expected.

  ヒドロキシピナコロン レチノエートが他の形態のビタミン A に比べて持つ 2 番目の重要な利点は、成分の安定性です。熱ストレス試験により、ヒドロキシピナコロンレチノエートは皮膚中で最大 15 時間安定して効果を維持することが示されています。